Methyl-Guard®

Thorne Methyl-Guard is a foundational methylation supplement that supports healthy heart, blood vessel, brain, and bone function. It brings together betaine, active folate (5-MTHF), methyl vitamin B12, and P5P in tissue-ready forms, so your body can use them without conversion. The formula may help maintain healthy homocysteine levels and support cardiovascular, cognitive, and bone health.

Active Nutrients for Healthy Methylation

Methylation is the process of adding a methyl group to another molecule, and it underpins neurotransmitters, detoxification, cardiovascular health, eye and muscle health, bone health, and redox balance. Thorne Methyl-Guard supplies the cofactors that drive this process. Folate as L-5-MTHF, vitamin B12 as methylcobalamin, and betaine help recycle homocysteine back to methionine. In addition, pyridoxal 5′-phosphate helps channel homocysteine into cysteine and taurine.

Because some people convert folic acid to active 5-MTHF less efficiently, Methyl-Guard uses the active 5-MTHF form directly. As a result, the formula suits adults whose methylation needs extra support, including older adults and those with common folate-conversion limitations.

Who Is Methyl-Guard Best For?

This methylation supplement suits adults wanting support for healthy homocysteine metabolism and overall methylation. It is a practical choice for ageing adults focused on cardiovascular and cognitive health, and for anyone with methylation-related genetic limitations affecting folate conversion. You can also explore more options for optimal health or browse the full Thorne range.

Key Benefits

• Supports healthy methylation for cardiovascular, cognitive, and bone health
• Helps maintain healthy homocysteine levels
• Supports heart, blood vessel, cognitive, nerve, bone, and female reproductive health
• Supports healthy brain function
• Supports homocysteine metabolism with active nutrient cofactors
• Supports detoxification-related biochemical pathways

How to Use Thorne Methyl-Guard

Take 3 capsules two times daily, or as recommended by your health-care practitioner. Spread your doses across the day for consistent methylation support, and swallow the capsules whole with water.

Product Details

• Brand: Thorne
• Product: Methyl-Guard
• Size: 180 capsules (60 servings)
• Serving size: 3 capsules
• Form: Capsule
• Key ingredients: Betaine anhydrous (trimethylglycine), folate as L-5-MTHF, vitamin B12 as methylcobalamin, vitamin B6 as P5P
• Dietary attributes: Gluten free, dairy free, soy free

Important Information

This product is contraindicated in individuals with a history of hypersensitivity to any of its ingredients. If you are pregnant or nursing, consult your health-care practitioner before use. Because Methyl-Guard contains folate, it is not recommended during methotrexate cancer therapy; however, folate has not been shown to interfere with the anti-inflammatory activity of methotrexate taken for psoriasis or rheumatoid arthritis. Always read the label and follow the directions for use.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.